Can Sulforaphane Help To Reduce Helicobacter Pylori (H. pylori)?
Helicobacter pylori (H. pylori) are bacteria which can commonly be present in the stomach, are easily transmissible and may cause symptoms when they start to multiply and reach higher levels. Conventional eradication of H. pylori is typically challenging and there is heightened interest in dietary strategies that may provide additional support. In this article we take a closer look at emerging links between H. pylori and sulforaphane, an incredible bioactive compound derived from cruciferous vegetables that is showing significant promise in this area.
What is H. pylori?
H. pylori are bacteria that can be transmitted from person to person and can colonise the stomach. H. pylori are very common, and are estimated to be present in around 50 – 75% of the world’s population. They can multiply in the mucus layer of the stomach lining and secrete an enzyme called urease which converts urea into ammonia. This then helps the bacteria to protect themselves against stomach acid. As the H. pylori multiply they damage the stomach tissue which can cause gastritis (irritated and inflamed stomach lining) and stomach ulcer.
There is much scientific debate on H. pylori among microbiologists; with some evidence to suggest that it may even confer benefits to the host at lower levels.1 However, H. pylori can also cause gastritis, gastric ulcer and more rarely an increased risk of stomach cancer. Currently, conventional recommendations are that H. pylori infection be treated with triple antibiotic therapy when symptoms are present. Only around 20% of those infected have symptoms which may include dull or burning stomach pain, weight loss, bloating, indigestion, nausea and (bloody) vomit.
What is Sulforaphane?
Cruciferous vegetables contain sulphur-containing compounds called glucosinolates. One particularly noteworthy glucosinolate compound is called glucoraphanin and this is found in particularly high levels in broccoli and broccoli sprouts.
When the broccoli plant is injured (such as when it is chopped or chewed) an enzyme called myrosinase catalyses the conversion of glucoraphanin into sulforaphane. Sulforaphane is a bioactive compound which has an important role to play in activation of the Nrf2 pathway which is extremely important for regulating our protective cellular enzymes and proteins, including many with antioxidant and detoxification functions such as glutathione and quinone reductase enzymes. Read more about this here.
So, what’s the link between H. pylori & Sulforaphane?
In a 2009 randomised controlled trial led by Dr Jed Fahey and published in Cancer Prevention Research, 48 patients infected with H. pylori were randomly assigned to 70g/day broccoli sprouts (containing 420 micromol sulforaphane precursor) or equal weight of alfalfa sprouts as placebo for 8 weeks. Results showed that intervention with broccoli sprouts, but not with placebo, decreased the levels of urease measured by the urea breath test and H. pylori stool antigen (both biomarkers of H. pylori colonisation) and serum pepsinogens I and II (biomarkers of gastric inflammation). Values recovered to their original levels 2 months after treatment was discontinued.2
Scientists are still unsure of the exact mechanisms behind why sulforaphane is able to reduce H. pylori colonisation, however these results are certainly encouraging, and as research into the wider benefits of sulforaphane continue, it’s definitely one to watch.
What’s the best way to increase your intake of sulforaphane?
Sulforaphane is not very stable and is highly reactive, whereas its precursor glucoraphanin is very stable. Broccoli sprouts are the best dietary source of glucoraphanin. You can also take glucoraphanin derived from broccoli seeds in supplement form and this is best supplied with a source of myrosinase such as mustard seed powder to support its conversion to sulforaphane.
1. Blaser MJ & Atherton JC. Helicobacter pylori persistence: biology and disease. The Journal of Clinical Investigation. Published February 1 2004. 10.1172/JCI20925
2. Yanaka A, Fahey JW, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila). 2009 Apr;2(4):353-60.
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